Rapid entry to phenanthroindolizidine alkaloids via an acid-catalysed acyliminium ion-electrocyclization cascade

Organic & Biomolecular Chemistry Journal, 2023, 21, 8075-8078
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Abstract: St. Pierre, M., C.J. Kempthorne, D.K. Liscombe and J. McNulty. A rapid total synthesis of seco-phenanthroindolizidine alkaloids was achieved involving a one-pot acid catalyzed deprotection- condensation-electrocyclization strategy. This synthetic route provided a concise synthesis of (±)-seco-antofine and (±)-septicine in only 4 steps with an overall yield of 22% and 17%, respectively.

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